# retatrutidedose.com

> An independent editorial project about the doses of retatrutide (LY3437943) used in published clinical trials: 0.5 to 12 mg once weekly, the escalation schedules, and the results at each dose. Every figure is sourced to a peer-reviewed paper with a verified DOI or a ClinicalTrials.gov entry. Retatrutide is an investigational compound, not approved by the FDA or the EMA; the site reports trial doses and does not give dosing advice.

## Key facts
- Phase 2 obesity trial (NEJM 2023, DOI 10.1056/NEJMoa2301972): 1, 4, 8 and 12 mg once weekly for 48 weeks; mean weight change -8.7%, -17.1%, -22.8%, -24.2% versus -2.1% placebo.
- Phase 2 type 2 diabetes trial (Lancet 2023, DOI 10.1016/S0140-6736(23)01053-X): 0.5, 4, 8 and 12 mg; HbA1c at 24 weeks -0.43 to -2.02 points.
- Phase 3 program: 4, 9 and 12 mg (TRIUMPH-1, TRIUMPH-2, TRANSCEND-T2D-1), 9 and 12 mg (TRIUMPH-3, TRIUMPH-4); 16 weeks escalation, 64 weeks maintenance.
- Half-life approximately 6 days (Lancet 2022, DOI 10.1016/S0140-6736(22)02033-5).

## Pages
- [Retatrutide dosage guide](https://retatrutidedose.com/): every trial dose, escalation and results, the summary page.
- [Dosing schedule](https://retatrutidedose.com/retatrutide-dosing-schedule): week-by-week schedules of each trial.
- [Reconstitution](https://retatrutidedose.com/retatrutide-reconstitution): concentration math with a calculator.
- [How it was taken](https://retatrutidedose.com/retatrutide-administration-in-trials): route, frequency, what protocols specify.
- [Cycle length](https://retatrutidedose.com/retatrutide-trial-duration): why trials never cycled it; durations.
- [Retatrutide vs Mounjaro](https://retatrutidedose.com/retatrutide-vs-mounjaro): dose ladders and trial results compared.
- [Results by dose](https://retatrutidedose.com/retatrutide-results): every published number by dose.
- [Half-life](https://retatrutidedose.com/retatrutide-half-life): 6 days and what it implies.
- [Titration](https://retatrutidedose.com/retatrutide-titration): 2 mg vs 4 mg starts, slow vs fast escalation.
- [5, 10 and 20 mg vials](https://retatrutidedose.com/retatrutide-5mg-10mg-20mg-vials): vial content versus trial dose.
- [Dose in type 2 diabetes](https://retatrutidedose.com/retatrutide-dose-type-2-diabetes): phase 2 and phase 3 data.
- [Phase 3 doses](https://retatrutidedose.com/retatrutide-phase-3-doses-triumph): TRIUMPH and TRANSCEND.
- [About](https://retatrutidedose.com/about)
- [Editorial policy](https://retatrutidedose.com/editorial-policy)

## Contact
editor@retatrutidedose.com